所属部门：微生物与免疫研究中心   

   职称：青年研究员

   学历：博士

 电子邮箱：xiajingjing@ipm-gba.org.cn   

个人介绍

粤港澳大湾区精准医学研究院（广州）青年研究员、复旦大学生命科学学院双聘研究员。毕业于华中科技大学同济医学院-临床医学（六年制德语班）；德国马普所心肺所-药学 / 法兰克福大学医学院-理论医学博士（最优等学位）；曾任德国科隆大学衰老相关疾病细胞应激反应研发中心（CECAD）博士后、德国IUF莱布尼茨环境医学研究所-复旦大学联合博士后、复旦大学人类表型组研究院助理研究员。

合作导师

王久存，复旦大学生命科学学院、人类表型组研究院和附属华山医院教授、博导、PI，复旦大学人类遗传学与人类学系主任，复旦大学风湿免疫过敏性疾病研究中心副主任，皮肤表型组学研究联合实验室共同主任；中国医学科学院皮肤及皮肤病群体遗传学和防控新技术研究创新单元共同主任；上海市人类学学会会长，上海市遗传学会秘书长，中日医学科技交流协会氢分子生物医学专业委员会副主任委员；联合发起硬皮病临床与研究国际协作网（InSCAR）并任副理事长。先后承担国家国际科技合作专项、国家自然科学基金重点及面上、中国医学科学院创新单元、上海市级重大专项示范课题、NIH-U01（地区PI）等项目。发表论文200余篇，其中以通讯作者在 Blood、Ann Rheum Dis、Microbiome等杂志发表论文80余篇。任Laborotary Investigation、Journal of Scleroderma and Related Disease等杂志编委。

研究方向

· 人体皮肤微生物组

利用多组学（宏基因组、皮肤表型组、代谢组）研究皮肤微生物组与皮肤健康的关系，目标是开发基于微生物的标志物和新疗法（益生元、益生菌和活体生物治疗产品），重塑宿主皮肤稳态。

• 上皮组织的稳态维持

与IUF莱布尼茨环境医学研究所（德国）的Krutmann院士合作，研究环境暴露组与皮肤老化的关系；解析“环境传感器”芳基烃受体（AHR）在维持皮肤屏障中的作用。

· 硬皮病等难治性纤维化疾病的细胞治疗药物开发

与复旦大学生科院王久存教授紧密合作，研究脂肪来源的修复细胞（Adipose Derived Regenerative cells, ADRCs）在难治性纤维化疾病中的作用；参与临床前机制研究及IIT等临床研究。

论文

· Huizhen Chen, Qi Zhao, Qian Zhong, Cheng Duan, Jean Krutmann, Jiucun Wang*, Jingjing Xia*；Skin microbiome, metabolome and skin phenome, from the perspectives of skin as an ecosystem. Phenomics; 2022.

· Qingzhen Wei, Zhiming Li, Xiao Liu, Jean Krutmann*, Jiucun Wang*, Jingjing Xia*; Shotgun metagenomic sequencing reveals skin microbial variability from different facial sites. Frontiers in Microbiology; 2022 Jul 26; 13:933189.

· Zhiming Li#; Jingjing Xia#; Liuyiqi Jiang#; Yimei Tan#; Yitai An; Xingyu Zhu; Jie Ruan; Zhihua Chen; Hefu Zhen; Yanyun Ma; Zhuye Jie; Liang Xiao; Huanming Yang; Jian Wang; Karsten Kristiansen; Xun Xu; Li Jin; Chao Nie*; Jean Krutmann*; Xiao Liu*; Jiucun Wang*; Characterization of the human skin resistome and identification of two microbiota cutotypes. Microbiome; 2021; 9(1): 47.

· Xingyu Zhu; Liuyiqi Jiang; Qian Zhong; Xiangzhen Kong; Rui Zhang; Lingxian Zhu; Qingmei Liu; Wenyu Wu; Yimei Tan; Jiucun Wang*; Jingjing Xia*; Abnormal expression of interleukin-6 is associated with epidermal alternations in localized scleroderma. Clinical Rheumatology; 2022 Mar 12.

· Jingjing Xia; Thomas Worzfeld; Semaphorins and Plexins in Kidney Disease. Nephron; 2016; 132.

· Jingjing Xia; Jakub M Swiercz; Inmaculada Banon-Rodriguez; Ivana Matkovic; Giuseppina Federico; Tianliang Sun; Timo Franz; Cord H Brakebusch; Atsushi Kumanogoh; Roland H Friedel; Fernando Martin-Belmonte; Hermann-Josef Grone; Stefan Offermanns; Thomas Worzfeld*; Semaphorin-Plexin Signaling Controls Mitotic Spindle Orientation during Epithelial Morphogenesis and Repair. Developmental Cell; 2015; 33(3): 299-313. (F1000 recommendation)

· Junjie Luo, Shiwei Shen, Jingjing Xia, Jiucun Wang & Zhenglong Gu*; Mitochondria as the Essence of Yang Qi in the Human Body. Phenomics; 2022.

· Zhao Z, Chu J, Xu X, Cao Y, Schikowski T, Geng M, Chen G, Bai G, Hu K, Xia J, Ma W, Liu Q, Lu Z, Guo X, Zhao Q. Association between ambient cold exposure and mortality risk in Shandong Province, China: Modification effect of particulate matter size. Front Public Health. 2023 Jan 5; 10:1093588.

· Matthias Zielonka; Jingjing Xia; Roland H. Friedel; Stefan Offermanns; Thomas Worzfeld*; A systematic expression analysis implicates Plexin-B2 and its ligand Sema4C in the regulation of the vascular and endocrine system. Experimental Cell Research; 2010; 316(15): 2477-2486.

· Thomas Worzfeld*; Jakub M Swiercz; Aycan Senturk; Berit Genz; Alexander Korostylev; Suhua Deng; Jingjing Xia; Mikio Hoshino; Jonathan A Epstein; Andrew M Chan; Brigitte Vollmar; Amparo Acker-Palmer; Rohini Kuner; Stefan Offermanns; Genetic dissection of plexin signaling in vivo. Proceedings of the National Academy of Sciences of the United States of America; 2014; 111(6): 2194-2199.

· Jialu Jin; Jing Gong; Tiejun Yin; Yanjun Lu; Jingjing Xia; Yuyuan Xie; Yong Di; Lei He; Jianli Guo; Jun Sun; Mathieu HM Noteborn; Shen Qu; PTD4-apoptin protein and dacarbazine show a synergistic antitumor effect on B16-F1 melanoma in vitro and in vivo. European Journal of Pharmacology; 2011; 654(1):17-25

· Coulange Zavarro, Anouck, Mélanie Velier, Robin Arcani, Maxime Abellan Lopez, Stéphanie Simoncini, Audrey Benyamine, Quentin Gomes De Pinho, Raphael Coatmeur, Jiucun Wang, Jingjing Xia, Ludovica Barone, Dominique Casanova, Françoise Dignat-George, Florence Sabatier, Brigitte Granel, Jérémy Magalon, and Aurélie Daumas; Adipose Tissue and Adipose-Tissue-Derived Cell Therapies for the Treatment of the Face and Hands of Patients Suffering from Systemic Sclerosis. Biomedicines; 2023, 11, 348.

· Yunrong Ti#, Mengbo Yang#, Xinda Chen, Ming Zhang, Jingjing Xia, Xiangguo Lv, Dongdong Xiao*, Jiucun Wang*, Mujun Lu*; Comparison of the therapeutic effects of human umbilical cord blood-derived mesenchymal stem cells and adipose-derived stem cells on erectile dysfunction in a rat model of bilateral cavernous nerve injury. Frontiers in Bioengineering and Biotechnology; 2022; 10.

· X. Shi et al.; LDLR dysfunction induces LDL accumulation and promotes pulmonary fibrosis. Clinical and Translational Medicine; 2022; 12; e711

· Xiangguang Shi#; Qingmei Liu#; Han Zhao#; Jiaying Lu; Yan Huang; Yanyun Ma; Jingjing Xia; Mengguo Liu; Wenzhen Tu; Li Jin; Jiucun Wang; Yinhuan Zhao*; Wenyu Wu*; Increased expression of GAB1 promotes inflammation and fibrosis in systemic sclerosis. Experimental Dermatology; 2019; 28(11)：1313-1320.

专利 

• 用于皮肤分型的标志物组合及其应用, 2020-12-08, 中国, 申请专利号202011444009.3. 

项目

· 主持国自然青年项目、中国博士后面上项目；

· 参与十四五国家重点研发计划“生物大分子与微生物组”、中国医学科学院院外创新单元、上海市重大科技专项人类表型组计划等重大科技项目。

其它

· 2022年广州南沙高端领军人才-青年后备人才

· 法兰克福大学医学院-校友会奖

· 欧洲皮肤研究协会（ESDR）会员、美国皮肤研究协会（SID）会员

课题组长期招聘博士后，欢迎热爱科研、有想法、有冲劲的青年学者加入！