性别：男

 所属部门：原创新药研究中心   

    职称：研究员

 电子邮箱：cuijin@ipm-gba.org.cn   

    学历：博士

 研究方向：天然产物和药物分子合成方法学、多肽及偶联药物研究

个人介绍

崔进，粤港澳大湾区精准医学研究院（广州）原创新药研究中心研究员、博士生导师、复旦大学药学院双聘研究员，“珠江人才计划”青年拔尖人才。2015年于日本大阪大学获博士学位，先后任日本学术振兴会（JSPS）特别研究员、日本微生物化学研究所高级研究员、主任研究员。先后主持国家自然科学基金、日本国家级基金项目等。在J. Am. Chem. Soc.、Angew. Chem. Int. Ed.、Proc. Natl. Acad. Sci. USA. 、Chem. Sci.、Org. Lett.等国际学术期刊发表论文二十余篇。课题组致力于天然产物和药物分子合成方法学、多肽及偶联药物研究等领域。

本课题组长期招聘博士后，诚挚欢迎优秀青年学者加入团队!

代表性论文专著

1.Samanta, S.; Noda, H.; Watanabe, T.*; Cui, J.*; Shibasaki, M.* Direct Catalytic Asymmetric Conjugate Addition of Benzofuran-3(2H)-ones to α,β-Unsaturated Thioamides: Stereodivergent Synthesis of Rocaglaol. Angew. Chem. Int. Ed. 2024, e202415805. doi: 10.1002/anie.202415805.

2.Samanta, S.; Cui, J.*; Otsuka, Y.; Watanabe, T.*; Shibasaki, M.* Direct Catalytic Enantioselective Conjugate Addition of α-Substituted Benzyl Nitriles to Alkyl Acrylates. Org. Lett. 2024, 26, 2255-2259.

3.Cui, J.*; Oriez, R.; Samanta, S.; Noda, H.*; Watanabe, T.; Shibasaki, M.* Catalytic Asymmetric Vinylogous Conjugate Addition of Butenolide to 2-Ester-Substituted Chromones: Access to Chiral Chromanone Lactones via Trapping of a Copper(I) Enolate by Trimethyl Borate. Org. Lett. 2023, 25, 8367-8371.

4.Cui, J.*; Samanta, S.; Watanabe, T.; Shibasaki, M.* Brønsted Base-Catalyzed Direct 1,6-Conjugate Addition of Butenolide to p-Quinone Methides. Asian J. Org. Chem. 2023, 12, e202300176. 

5.Samanta, S.; Cui, J.; Noda, H.; Watanabe, T.; Shibasaki, M. Asymmetric Syn-Selective Vinylogous Addition of Butenolides to Chromones via ALB Catalysis. J. Org. Chem. 2022, 88, 1177-1184. 

6.Cui, J.; Ogasawara, Y.; Kurata, I.; Matoba, K.; Fujioka, Y.; Noda, N. N.; Shibasaki, M.; Watanabe T. Targeting the ATG5-ATG16L1 protein-protein interaction with a hydrocarbon-stapled peptide derived from ATG16L1 for autophagy inhibition. J. Am. Chem. Soc. 2022, 144, 17671-17679. Selected as Supplementary Cover

7.Cui, J.*; Oriez, R.; Noda, H.; Watanabe, T.; Shibasaki, M.* Concise and stereodivergent approach to chromanone lactones through copper-catalyzed asymmetric vinylogous addition of siloxyfurans to 2-ester-substituted chromones. Angew. Chem. Int. Ed. 2022, 61, e202203128. Selected as Inside Back Cover

8.Cui, J.; Kumagai, N.; Watanabe, T.; Shibasaki, M. Direct catalytic asymmetric and anti-selective vinylogous addition of butenolides to chromones. Chem. Sci. 2020, 11, 7170-7176. Highlighted in Synfacts 2020, 16, 1079.

9.Yamagami, M.; Tsuchikawa, H.; Cui, J.; Umegawa, Y.; Miyazaki, Y.; Seo, S.; Shinoda, W.; Murata, M. Average conformation of branched-chain lipid PGP-Me that accounts for the thermal stability and high-salinity resistance of archaeal membranes. Biochemistry, 2019, 58, 3869-3879. 

10.Cui, J.; Ohtsuki, A.; Watanabe, T.; Kumagai, N.; Shibasaki, M. Direct catalytic asymmetric aldol reaction of thioamide with an α‐vinyl appendage. Chem. Eur. J. 2018, 24, 2598-2601. Highlighted in Synfacts 2018, 14, 0383.

11.Cui, J.; Morita, M.; Ohno, O.; Kimura, T.; Teruya, T.; Watanabe, T.; Suenaga, K.; Shibasaki, M. Leptolyngbyolides, cytotoxic macrolides from the marine cyanobacterium leptolyngbya sp.: isolation, biological activity, and catalytic asymmetric total synthesis. Chem. Eur. J. 2017, 23, 8500-8509.

12.Sahara, Y.; Cui, J.; Furutachi, M.; Chen, J. B.; Watanabe, T.; Shibasaki, M. Catalytic asymmetric synthesis of the C1-C15 segment of spirastrellolide A. Synthesis 2017, 49, 69-75. 

13.Cui, J.; Watanabe, T.; Shibasaki, M. Catalytic asymmetric synthesis of key intermediate for scytophycin C. Tetrahedron Lett. 2016, 57, 446-448. 

14.Cui, J.; Lethu, S.; Yasuda, T.; Matsuoka, S.; Matsumori, N.; Sato, F.; Murata, M. Phosphatidylcholine bearing 6,6-dideuterated oleic acid: a useful solid-state 2H NMR probe for investigating membrane properties. Bioorg. Med. Chem. Lett. 2015, 25, 203-206. 

15.Ando, J.; Kinoshita, M.; Cui, J.; Yamakoshi, H.; Dodoa, K.; Fujita, K.; Murata, M.; Sodeoka, M. Sphingomyelin distribution in lipid rafts of artificial monolayer membranes visualized by Raman microscopy. Proc. Natl. Acad. Sci. USA. 2015, 112, 4558-4563.

16.Cui, J.; Matsuoka, S.; Kinoshita, M.; Matsumori, N.; Sato, F.; Murata, M.; Ando, J.; Yamakoshi, H.; Dodo, K.; Sodeoka, M. Novel Raman-tagged sphingomyelin that closely mimics original raft-forming behavior. Bioorg. Med. Chem. 2015, 23, 2989-2994.   

17.Cui, J.; Kawatake, S.; Umegawa, Y.; Lethu, S.; Yamagami, M.; Matsuoka, S.; Sato, F.; Matsumori, N.; Murata, M. Stereoselective synthesis of the head group of archaeal phospholipid PGP-Me to investigate bacteriorhodopsin-lipid interactions. Org. Biomol. Chem. 2015, 13, 10279-10284.

(*: Corresponding author)

荣誉获奖： 珠江人才计划青年拔尖人才（2023）

        日本药学会(关东)青年科学家奖（2022）

        第九届国际功能有机化合物论坛(IFOC-9)最佳海报奖（2018）

        日本学术振兴会(JSPS)特别研究员基金（2015）

        日本文部科学省(MEXT)奖学金（2012）