性别：女

 所属部门：类器官与再生医学研究中心   

    职称：青年研究员

 电子邮箱：tangxiaofang@ipm-gba.org.cn   

    学历：博士

 研究方向：肺的发育、稳态维持以及损伤修复

个人介绍

   2006年本科毕业于清华大学，于2012年博士毕业于美国辛辛那提大学/辛辛那提儿童医院，之后继续于辛辛那提儿童医院从事呼吸系统的研究工作，于2022年4月加入粤港澳大湾区精准医学研究院（广州）类器官与再生医学研究中心担任青年研究员，具有丰富的遗传、发育、分子和细胞生物学的研究经验，曾主持美国国立卫生院（NIH）LRRC青年研究员先锋项目一项并作为主要研究人员参与NIH R01科研基金三项，在包括Journal of Clinical Investigation，Developmental Cell， Cell Death and Differentiation等杂志上发表SCI论文多篇，撰写专业著作章节一本，总引用712次。

研究方向

  聚焦于蛋白质质量控制体系以及表观遗传调控在肺上皮细胞的发育、稳态与损伤修复中的作用，并研究呼吸系统疾病尤其是包括肺纤维化在内的间质性肺病的发生发展机制以及治疗手段。

代表性著作

 1.Qinghang Meng*, Xiaofang Tang*, James Gulick, Hanna Osinska, Jeanne James, Wei Wei, John Snowball, Ronald J. Vagnozzi, Xinhua Lin, Jeffrey Whitsett, Jeffrey Robbins#, Jeffery D. Molkentin#. EMC3 Regulates Protein Homeostasis in the Cardiovascular System. (*equal contribution, #correspondence) (under revision in Circulation Research)

 2.Xiaofang Tang, Wei Wei, John M. Snowball, Ernesto S. Nakayasu, Sheila Bell, Charles Ansong, Xinhua Lin#, Jeffrey A. Whitsett#. (2022) EMC3 regulates mesenchymal cell survival via control of the mitotic spindle assembly. iScience. doi: https://doi.org/10.1016/j.isci.2022.105667.

 3.Wei Wei, Xiaofang Tang, Ning Jiang, Chao Ni, Hua He, Shenfei Sun, Meng Yu, Chuyue Yu, Mengdi Qiu, Dong Yan, Zhaocai Zhou, Yuanlin Song, Hanmin Liu, Bing Zhao, and Xinhua Lin. (2022). Chromatin remodeler Znhit1 controls bone morphogenetic protein signaling in embryonic lung tissue branching. J Biol Chem 298, 102490.10.1016/j.jbc.2022.102490.

 4.Xiaofang Tang, John M. Snowball, Yan Xu, Cheng-Lun Na, Timothy E. Weaver, Geremy Clair, Jennifer E. Kyle, Erika M. Zink, Charles Ansong, Wei Wei, Meina Huang, Xinhua Lin, Jeffrey A. Whitsett. (2017) EMC3 coordinates surfactant protein and lipid homeostasis required for respiration. Journal of Clinical Investigation 127, 4314-4325, doi:10.1172/JCI94152 (2017).

 5.Qinzhu Huang*, Xiaofang Tang*, Guolun Wang*, Yun Fan, Andreas Bergmann, Dongsheng Yan, Yi Lin, Xiaolei Ye, Xiaolan Fan, Xiangtian Zhou, Fan Lu, Jia Qu, Xinhua Lin. (2014) Ubr3 E3 ligase regulates apoptosis by controlling the activity of DIAP1 in Drosophila. Cell Death & Differentiation 21, 1961-1970. (*equal contribution)

 6.Qinghang Meng, Maureen Mongan, Jingjing Wang, Xiaofang Tang, Jinling Zhang, Winston Kao, Ying Xia. (2014) Epithelial sheet movement requires the cooperation of c-Jun and MAP3K1. Developmental Biology 395(1), 29-37.

 7.Guolun Wang*, Xiaofang Tang*, Yujie Chen, Jun Cao, Qinzhu Huang, Xuemei Ling, Wenyan Ren, Songqing Liu, Yihui Wu, Lorraine Ray, Xinhua Lin. (2014) Hyperplastic discs differentially regulates the transcriptional outputs of hedgehog signaling. Mechanisms of Development 133, 117-25. (*equal contribution)

 8.Xiaofang Tang*, Yihui Wu*, Tatyana Y. Belenkaya, Qinzhu Huang, Lorraine Ray, Jia Qu, Xinhua Lin. (2012) Roles of N-glycosylation and lipidation in Wg secretion and signaling. Developmental Biology 364, 32-41. (*equal contribution)

 9.Xiaofang Tang, Xiaolan Fan, Xinhua Lin. (2010) Regulation of Wnt secretion and distribution. In: Targeting the Wnt pathway in cancer. Springer. p. 19-33 

  10.Dong Yan, Yihui Wu, Yongfei Yang, Tatyana Y. Belenkaya, Xiaofang Tang and Xinhua Lin. (2010) The cell-surface proteins Dally-like and Ihog differentially regulate Hedgehog signaling strength and range during development. Development 137, 2033-44.

 11.Wei Wang, Wenke Liu, Yue Wang, Liya Zhou, Xiaofang Tang and Hong Luo. (2010) Notch signaling regulates neuroepithelial stem cell maintenance and neuroblast formation in Drosophila optic lobe development. Developmental Biology 350, 414-28.

 12.Tatyana Y. Belenkaya, Yihui Wu*, Xiaofang Tang*, Bo Zhou, Longqiu Cheng, Yagya V. Sharma, Dong Yan, Erica M. Selva and Xinhua Lin. (2008) The retromer complex influences wnt secretion by recycling wntless from endosomes to the trans-Golgi network. Developmental Cell 14, 120-31. (*equal contribution)